NTRK, ALK, and ROS1 Fusions in Salivary Gland Tumors
Salivary glands are located in the mouth and throat; they produce digestive enzymes and saliva and that keeps their surrounding area from feeling dry. Of the three major pairs of salivary glands under and behind the jaw (the parotid, sublingual and submandibular), the largest salivary glands are the parotid glands, located just in front of and below each ear. The parotid glands are frequently involved in disease processes, and most salivary gland cancers begin with parotid gland tumors.
Types of Salivary Gland Cancers
There are numerous types of cancer that can affect the salivary glands, with the name of the cancer generally referring to the cells in which the cancer formation began. Some specific salivary gland cancers include:
- Acinic cell carcinoma
- Squamous cell carcinoma
- Mucoepidermoid cancer
- Parotid gland tumors
- Anaplastic carcinoma
- Poorly differentiated carcinoma
The American Cancer Society estimates that roughly 3,200 new people will be diagnosed with a form of salivary gland cancer each year in the United States. This disease may arise in children or adults, with prior tobacco and alcohol use associated with its development.
If you or a loved one have been diagnosed with salivary gland cancer, including parotid gland cancer, it is important to be evaluated for enrollment in the STARTRK-2 trial.
See if you or a loved one may be eligible for the study.